Plasminogen activator inhibitor 1 (SERPINE1)

About Plasminogen activator inhibitor 1

Plasminogen activator inhibitor 1 (SERPINE1) is a protein from Homo sapiens identified by UniProt accession P05121, 402 residues long. MolForge cross-references it against 0 known binders and 1,068 disease associations.

Target properties

Protein name	Plasminogen activator inhibitor 1
UniProt accession	P05121
Gene	SERPINE1
Organism	Homo sapiens
Length	402 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (1068)

Diseases linked to this target (Open Targets).

congenital plasminogen activator inhibitor type 1 deficiency · score 0.71
blood protein measurement · score 0.32
plasminogen activator inhibitor 1 measurement · score 0.27
Abnormal bleeding · score 0.27
breast adenocarcinoma · score 0.26
body height · score 0.26
erythrocyte count · score 0.25
mean corpuscular hemoglobin · score 0.19
glioblastoma multiforme · score 0.17
hemorrhage · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P05121-F1	alphafold	PREDICTED	88.90	—

Amino-acid sequence (402 residues)

MQMSPALTCL VLGLALVFGE GSAVHHPPSY VAHLASDFGV RVFQQVAQAS KDRNVVFSPY GVASVLAMLQ LTTGGETQQQ IQAAMGFKID DKGMAPALRH LYKELMGPWN KDEISTTDAI FVQRDLKLVQ GFMPHFFRLF RSTVKQVDFS EVERARFIIN DWVKTHTKGM ISNLLGKGAV DQLTRLVLVN ALYFNGQWKT PFPDSSTHRR LFHKSDGSTV SVPMMAQTNK FNYTEFTTPD GHYYDILELP YHGDTLSMFI AAPYEKEVPL SALTNILSAQ LISHWKGNMT RLPRLLVLPK FSLETEVDLR KPLENLGMTD MFRQFQADFT SLSDQEPLHV AQALQKVKIE VNESGTVASS STAVIVSARM APEEIIMDRP FLFVVRHNPT GTVLFMGQVM EP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards