Plasma serine protease inhibitor (SERPINA5)

About Plasma serine protease inhibitor

Plasma serine protease inhibitor (SERPINA5) is a protein from Homo sapiens identified by UniProt accession P05154, 406 residues long. MolForge cross-references it against 0 known binders and 219 disease associations.

Target properties

Protein name	Plasma serine protease inhibitor
UniProt accession	P05154
Gene	SERPINA5
Organism	Homo sapiens
Length	406 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (219)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.47
sex hormone-binding globulin measurement · score 0.45
serum albumin measurement · score 0.43
total blood protein measurement · score 0.36
calcium measurement · score 0.30
CD27 antigen measurement · score 0.28
kallistatin measurement · score 0.27
lung adenocarcinoma · score 0.25
glioblastoma multiforme · score 0.24
cutaneous melanoma · score 0.23

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P05154-F1	alphafold	PREDICTED	85.14	—

Amino-acid sequence (406 residues)

MQLFLLLCLV LLSPQGASLH RHHPREMKKR VEDLHVGATV APSSRRDFTF DLYRALASAA PSQSIFFSPV SISMSLAMLS LGAGSSTKMQ ILEGLGLNLQ KSSEKELHRG FQQLLQELNQ PRDGFQLSLG NALFTDLVVD LQDTFVSAMK TLYLADTFPT NFRDSAGAMK QINDYVAKQT KGKIVDLLKN LDSNAVVIMV NYIFFKAKWE TSFNHKGTQE QDFYVTSETV VRVPMMSRED QYHYLLDRNL SCRVVGVPYQ GNATALFILP SEGKMQQVEN GLSEKTLRKW LKMFKKRQLE LYLPKFSIEG SYQLEKVLPS LGISNVFTSH ADLSGISNHS NIQVSEMVHK AVVEVDESGT RAAAATGTIF TFRSARLNSQ RLVFNRPFLM FIVDNNILFL GKVNRP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards