About Plasma protease C1 inhibitor
Plasma protease C1 inhibitor (SERPING1) is a protein
from Homo sapiens identified by UniProt accession
P05155, 500 residues long.
MolForge cross-references it against 0 known binders and
404 disease associations.
Target properties
| Protein name | Plasma protease C1 inhibitor |
|---|
| UniProt accession | P05155 |
|---|
| Gene | SERPING1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 500 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (404)
Diseases linked to this target (Open Targets).
- hereditary angioedema with C1Inh deficiency · score 0.82
- hereditary angioedema type 1 · score 0.74
- hereditary angioedema · score 0.67
- C1 inhibitor deficiency · score 0.62
- hereditary angioedema type 2 · score 0.59
- genetic disorder · score 0.54
- Bartholin gland disease · score 0.50
- immunodeficiency due to a classical component pathway complement deficiency · score 0.45
- blood protein measurement · score 0.43
- mean platelet volume · score 0.42
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P05155-F1 | alphafold | PREDICTED | 79.56 | — |
Amino-acid sequence (500 residues)
MASRLTLLTL LLLLLAGDRA SSNPNATSSS SQDPESLQDR GEGKVATTVI SKMLFVEPIL EVSSLPTTNS TTNSATKITA NTTDEPTTQP TTEPTTQPTI QPTQPTTQLP TDSPTQPTTG SFCPGPVTLC SDLESHSTEA VLGDALVDFS LKLYHAFSAM KKVETNMAFS PFSIASLLTQ VLLGAGENTK TNLESILSYP KDFTCVHQAL KGFTTKGVTS VSQIFHSPDL AIRDTFVNAS RTLYSSSPRV LSNNSDANLE LINTWVAKNT NNKISRLLDS LPSDTRLVLL NAIYLSAKWK TTFDPKKTRM EPFHFKNSVI KVPMMNSKKY PVAHFIDQTL KAKVGQLQLS HNLSLVILVP QNLKHRLEDM EQALSPSVFK AIMEKLEMSK FQPTLLTLPR IKVTTSQDML SIMEKLEFFD FSYDLNLCGL TEDPDLQVSA MQHQTVLELT ETGVEAAAAS AISVARTLLV FEVQQPFLFV LWDQQHKFPV FMGRVYDPRA
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