About Complement factor I
Complement factor I (CFI) is a protein
from Homo sapiens identified by UniProt accession
P05156, 583 residues long.
MolForge cross-references it against 0 known binders and
277 disease associations.
Target properties
| Protein name | Complement factor I |
|---|
| UniProt accession | P05156 |
|---|
| Gene | CFI |
|---|
| Organism | Homo sapiens |
|---|
| Length | 583 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (277)
Diseases linked to this target (Open Targets).
- atypical hemolytic-uremic syndrome with I factor anomaly · score 0.80
- complement factor I deficiency · score 0.79
- atypical hemolytic-uremic syndrome · score 0.65
- age-related macular degeneration · score 0.61
- non-immunoglobulin-mediated membranoproliferative glomerulonephritis · score 0.37
- atypical hemolytic uremic syndrome with complement gene abnormality · score 0.37
- Familial drusen · score 0.37
- C3 glomerulonephritis · score 0.20
- genetic disorder · score 0.19
- congenital afibrinogenemia · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P05156-F1 | alphafold | PREDICTED | 84.77 | — |
Amino-acid sequence (583 residues)
MKLLHVFLLF LCFHLRFCKV TYTSQEDLVE KKCLAKKYTH LSCDKVFCQP WQRCIEGTCV CKLPYQCPKN GTAVCATNRR SFPTYCQQKS LECLHPGTKF LNNGTCTAEG KFSVSLKHGN TDSEGIVEVK LVDQDKTMFI CKSSWSMREA NVACLDLGFQ QGADTQRRFK LSDLSINSTE CLHVHCRGLE TSLAECTFTK RRTMGYQDFA DVVCYTQKAD SPMDDFFQCV NGKYISQMKA CDGINDCGDQ SDELCCKACQ GKGFHCKSGV CIPSQYQCNG EVDCITGEDE VGCAGFASVT QEETEILTAD MDAERRRIKS LLPKLSCGVK NRMHIRRKRI VGGKRAQLGD LPWQVAIKDA SGITCGGIYI GGCWILTAAH CLRASKTHRY QIWTTVVDWI HPDLKRIVIE YVDRIIFHEN YNAGTYQNDI ALIEMKKDGN KKDCELPRSI PACVPWSPYL FQPNDTCIVS GWGREKDNER VFSLQWGEVK LISNCSKFYG NRFYEKEMEC AGTYDGSIDA CKGDSGGPLV CMDANNVTYV WGVVSWGENC GKPEFPGVYT KVANYFDWIS YHVGRPFISQ YNV
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