Ubiquitin-like protein ISG15 (ISG15)

About Ubiquitin-like protein ISG15

Ubiquitin-like protein ISG15 (ISG15) is a protein from Homo sapiens identified by UniProt accession P05161, 165 residues long. MolForge cross-references it against 0 known binders and 375 disease associations.

Target properties

Protein name	Ubiquitin-like protein ISG15
UniProt accession	P05161
Gene	ISG15
Organism	Homo sapiens
Length	165 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (375)

Diseases linked to this target (Open Targets).

COVID-19 · score 0.47
influenza · score 0.37
blood protein measurement · score 0.22
total blood protein measurement · score 0.21
apolipoprotein A 1 measurement · score 0.13
high density lipoprotein cholesterol measurement · score 0.12
neoplasm · score 0.12
infection · score 0.12
infect · score 0.12
cancer · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P05161-F1	alphafold	PREDICTED	85.87	—

Amino-acid sequence (165 residues)

MGWDLTVKML AGNEFQVSLS SSMSVSELKA QITQKIGVHA FQQRLAVHPS GVALQDRVPL ASQGLGPGST VLLVVDKCDE PLSILVRNNK GRSSTYEVRL TQTVAHLKQQ VSGLEGVQDD LFWLTFEGKP LEDQLPLGEY GLKPLSTVFM NLRLRGGGTE PGGRS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards