About Propionyl-CoA carboxylase beta chain, mitochondrial
Propionyl-CoA carboxylase beta chain, mitochondrial (PCCB) is a protein
from Homo sapiens identified by UniProt accession
P05166, 539 residues long.
MolForge cross-references it against 0 known binders and
218 disease associations.
Target properties
| Protein name | Propionyl-CoA carboxylase beta chain, mitochondrial |
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| UniProt accession | P05166 |
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| Gene | PCCB |
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| Organism | Homo sapiens |
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| Length | 539 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (218)
Diseases linked to this target (Open Targets).
- propionic acidemia · score 0.87
- genetic disorder · score 0.51
- dilated cardiomyopathy · score 0.37
- Dilated cardiomyopathy · score 0.37
- Abnormality of metabolism/homeostasis · score 0.34
- high density lipoprotein cholesterol measurement · score 0.29
- triglyceride measurement · score 0.28
- neurodegenerative disease · score 0.27
- sex hormone-binding globulin measurement · score 0.23
- systolic blood pressure · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P05166-F1 | alphafold | PREDICTED | 93.30 | — |
Amino-acid sequence (539 residues)
MAAALRVAAV GARLSVLASG LRAAVRSLCS QATSVNERIE NKRRTALLGG GQRRIDAQHK RGKLTARERI SLLLDPGSFV ESDMFVEHRC ADFGMAADKN KFPGDSVVTG RGRINGRLVY VFSQDFTVFG GSLSGAHAQK ICKIMDQAIT VGAPVIGLND SGGARIQEGV ESLAGYADIF LRNVTASGVI PQISLIMGPC AGGAVYSPAL TDFTFMVKDT SYLFITGPDV VKSVTNEDVT QEELGGAKTH TTMSGVAHRA FENDVDALCN LRDFFNYLPL SSQDPAPVRE CHDPSDRLVP ELDTIVPLES TKAYNMVDII HSVVDEREFF EIMPNYAKNI IVGFARMNGR TVGIVGNQPK VASGCLDINS SVKGARFVRF CDAFNIPLIT FVDVPGFLPG TAQEYGGIIR HGAKLLYAFA EATVPKVTVI TRKAYGGAYD VMSSKHLCGD TNYAWPTAEI AVMGAKGAVE IIFKGHENVE AAQAEYIEKF ANPFPAAVRG FVDDIIQPSS TRARICCDLD VLASKKVQRP WRKHANIPL
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