About Cytochrome P450 2E1
Cytochrome P450 2E1 (CYP2E1) is a protein
from Homo sapiens identified by UniProt accession
P05181, 493 residues long.
MolForge cross-references it against 0 known binders and
393 disease associations.
Target properties
| Protein name | Cytochrome P450 2E1 |
|---|
| UniProt accession | P05181 |
|---|
| Gene | CYP2E1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 493 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (393)
Diseases linked to this target (Open Targets).
- Primary amenorrhea · score 0.32
- primary ovarian insufficiency · score 0.27
- glioblastoma multiforme · score 0.19
- body mass index · score 0.19
- cutaneous melanoma · score 0.18
- hepatocellular carcinoma · score 0.11
- acetone measurement · score 0.11
- lung adenocarcinoma · score 0.10
- Hypomaturation amelogenesis imperfecta · score 0.09
- Hypoplastic amelogenesis imperfecta · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P05181-F1 | alphafold | PREDICTED | 96.13 | — |
Amino-acid sequence (493 residues)
MSALGVTVAL LVWAAFLLLV SMWRQVHSSW NLPPGPFPLP IIGNLFQLEL KNIPKSFTRL AQRFGPVFTL YVGSQRMVVM HGYKAVKEAL LDYKDEFSGR GDLPAFHAHR DRGIIFNNGP TWKDIRRFSL TTLRNYGMGK QGNESRIQRE AHFLLEALRK TQGQPFDPTF LIGCAPCNVI ADILFRKHFD YNDEKFLRLM YLFNENFHLL STPWLQLYNN FPSFLHYLPG SHRKVIKNVA EVKEYVSERV KEHHQSLDPN CPRDLTDCLL VEMEKEKHSA ERLYTMDGIT VTVADLFFAG TETTSTTLRY GLLILMKYPE IEEKLHEEID RVIGPSRIPA IKDRQEMPYM DAVVHEIQRF ITLVPSNLPH EATRDTIFRG YLIPKGTVVV PTLDSVLYDN QEFPDPEKFK PEHFLNENGK FKYSDYFKPF STGKRVCAGE GLARMELFLL LCAILQHFNL KPLVDPKDID LSPIHIGFGC IPPRYKLCVI PRS
Explore Cytochrome P450 2E1 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets