About Alkaline phosphatase, placental type
Alkaline phosphatase, placental type (ALPP) is a protein
from Homo sapiens identified by UniProt accession
P05187, 535 residues long.
MolForge cross-references it against 0 known binders and
197 disease associations.
Target properties
| Protein name | Alkaline phosphatase, placental type |
|---|
| UniProt accession | P05187 |
|---|
| Gene | ALPP |
|---|
| Organism | Homo sapiens |
|---|
| Length | 535 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (197)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.36
- body height · score 0.14
- lean body mass · score 0.10
- neoplasm · score 0.09
- DNA methylation · score 0.08
- fat body mass · score 0.08
- Facioscapulohumeral dystrophy · score 0.08
- facioscapulohumeral muscular dystrophy · score 0.08
- Zika virus infectious disease · score 0.07
- body weight · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P05187-F1 | alphafold | PREDICTED | 93.41 | — |
Amino-acid sequence (535 residues)
MLGPCMLLLL LLLGLRLQLS LGIIPVEEEN PDFWNREAAE ALGAAKKLQP AQTAAKNLII FLGDGMGVST VTAARILKGQ KKDKLGPEIP LAMDRFPYVA LSKTYNVDKH VPDSGATATA YLCGVKGNFQ TIGLSAAARF NQCNTTRGNE VISVMNRAKK AGKSVGVVTT TRVQHASPAG TYAHTVNRNW YSDADVPASA RQEGCQDIAT QLISNMDIDV ILGGGRKYMF RMGTPDPEYP DDYSQGGTRL DGKNLVQEWL AKRQGARYVW NRTELMQASL DPSVTHLMGL FEPGDMKYEI HRDSTLDPSL MEMTEAALRL LSRNPRGFFL FVEGGRIDHG HHESRAYRAL TETIMFDDAI ERAGQLTSEE DTLSLVTADH SHVFSFGGYP LRGSSIFGLA PGKARDRKAY TVLLYGNGPG YVLKDGARPD VTESESGSPE YRQQSAVPLD EETHAGEDVA VFARGPQAHL VHGVQEQTFI AHVMAFAACL EPYTACDLAP PAGTTDAAHP GRSVVPALLP LLAGTLLLLE TATAP
Explore Alkaline phosphatase, placental type with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets