Non-histone chromosomal protein HMG-17 (HMGN2)

About Non-histone chromosomal protein HMG-17

Non-histone chromosomal protein HMG-17 (HMGN2) is a protein from Homo sapiens identified by UniProt accession P05204, 90 residues long. MolForge cross-references it against 0 known binders and 84 disease associations.

Target properties

Protein name	Non-histone chromosomal protein HMG-17
UniProt accession	P05204
Gene	HMGN2
Organism	Homo sapiens
Length	90 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (84)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.54
forced expiratory volume · score 0.22
body height · score 0.22
lymphocyte count · score 0.21
vital capacity · score 0.21
leukocyte count · score 0.21
appendicular lean mass · score 0.20
type 2 diabetes mellitus · score 0.17
peak expiratory flow · score 0.16
lean body mass · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P05204-F1	alphafold	PREDICTED	67.00	—

Amino-acid sequence (90 residues)

MPKRKAEGDA KGDKAKVKDE PQRRSARLSA KPAPPKPEPK PKKAPAKKGE KVPKGKKGKA DAGKEGNNPA ENGDAKTDQA QKAEGAGDAK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards