Fibroblast growth factor 1 (FGF1)

About Fibroblast growth factor 1

Fibroblast growth factor 1 (FGF1) is a protein from Homo sapiens identified by UniProt accession P05230, 155 residues long. MolForge cross-references it against 0 known binders and 465 disease associations.

Target properties

Protein name	Fibroblast growth factor 1
UniProt accession	P05230
Gene	FGF1
Organism	Homo sapiens
Length	155 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (465)

Diseases linked to this target (Open Targets).

cancer · score 0.61
bone development disease · score 0.60
female reproductive endometrioid cancer · score 0.50
BMI-adjusted waist-hip ratio · score 0.50
ovarian carcinoma · score 0.47
waist-hip ratio · score 0.45
heel bone mineral density · score 0.43
prostate cancer · score 0.37
neurodegenerative disease · score 0.37
craniosynostosis · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P05230-F1	alphafold	PREDICTED	90.67	—

Amino-acid sequence (155 residues)

MAEGEITTFT ALTEKFNLPP GNYKKPKLLY CSNGGHFLRI LPDGTVDGTR DRSDQHIQLQ LSAESVGEVY IKSTETGQYL AMDTDGLLYG SQTPNEECLF LERLEENHYN TYISKKHAEK NWFVGLKKNG SCKRGPRTHY GQKAILFLPL PVSSD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards