Endothelin-1 (EDN1)

Homo sapiens — UniProt P05305

Gene: EDN1Homo sapiensSwissProt reviewed

About Endothelin-1

Endothelin-1 (EDN1) is a protein from Homo sapiens identified by UniProt accession P05305, 212 residues long. MolForge cross-references it against 0 known binders and 1,287 disease associations.

Target properties

Protein nameEndothelin-1
UniProt accessionP05305
GeneEDN1
OrganismHomo sapiens
Length212 residues
Molecular weight—
EC numbers—
Target classUNCLASSIFIED
Subcellular location—
Keywords—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tierMEDIUM
Druggability score—
Pocket score—
Max clinical phase—

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

StructureSourceMethodMean pLDDTResolution (Å)
AF-P05305-F1alphafoldPREDICTED65.21—

Amino-acid sequence (212 residues)

MDYLLMIFSL LFVACQGAPE TAVLGAELSA VGENGGEKPT PSPPWRLRRS KRCSCSSLMD KECVYFCHLD IIWVNTPEHV VPYGLGSPRS KRALENLLPT KATDRENRCQ CASQKDKKCW NFCQAGKELR AEDIMEKDWN NHKKGKDCSK LGKKCIYQQL VRGRKIRRSS EEHLRQTRSE TMRNSVKSSF HDPKLKGKPS RERYVTHNRA HW

Explore Endothelin-1 with MolForge

Find binders, run structure-based screening, and map this target across diseases and approved drugs with our AI-powered platform.

Browse all targets

Quick facts

UniProtP05305
GeneEDN1
OrganismHomo sapiens
Length212
Binders0
Diseases1,287
View on UniProt