About Intercellular adhesion molecule 1
Intercellular adhesion molecule 1 (ICAM1) is a protein
from Homo sapiens identified by UniProt accession
P05362, 532 residues long.
MolForge cross-references it against 0 known binders and
1,459 disease associations.
Target properties
| Protein name | Intercellular adhesion molecule 1 |
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| UniProt accession | P05362 |
|---|
| Gene | ICAM1 |
|---|
| Organism | Homo sapiens |
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| Length | 532 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (1459)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- Crohn's disease · score 0.33
- leukocyte count · score 0.30
- ICAM-1 measurement · score 0.30
- lymphocyte count · score 0.29
- myeloid white cell count · score 0.27
- pouchitis · score 0.26
- glioblastoma multiforme · score 0.21
- head and neck squamous cell carcinoma · score 0.20
- ovarian cancer · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P05362-F1 | alphafold | PREDICTED | 88.42 | — |
Amino-acid sequence (532 residues)
MAPSSPRPAL PALLVLLGAL FPGPGNAQTS VSPSKVILPR GGSVLVTCST SCDQPKLLGI ETPLPKKELL LPGNNRKVYE LSNVQEDSQP MCYSNCPDGQ STAKTFLTVY WTPERVELAP LPSWQPVGKN LTLRCQVEGG APRANLTVVL LRGEKELKRE PAVGEPAEVT TTVLVRRDHH GANFSCRTEL DLRPQGLELF ENTSAPYQLQ TFVLPATPPQ LVSPRVLEVD TQGTVVCSLD GLFPVSEAQV HLALGDQRLN PTVTYGNDSF SAKASVSVTA EDEGTQRLTC AVILGNQSQE TLQTVTIYSF PAPNVILTKP EVSEGTEVTV KCEAHPRAKV TLNGVPAQPL GPRAQLLLKA TPEDNGRSFS CSATLEVAGQ LIHKNQTREL RVLYGPRLDE RDCPGNWTWP ENSQQTPMCQ AWGNPLPELK CLKDGTFPLP IGESVTVTRD LEGTYLCRAR STQGEVTRKV TVNVLSPRYE IVIITVVAAA VIMGTAGLST YLYNRQRKIK KYRLQQAQKG TPMKPNTQAT PP
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