Large ribosomal subunit protein P1 (RPLP1)

About Large ribosomal subunit protein P1

Large ribosomal subunit protein P1 (RPLP1) is a protein from Homo sapiens identified by UniProt accession P05386, 114 residues long. MolForge cross-references it against 0 known binders and 111 disease associations.

Target properties

Protein name	Large ribosomal subunit protein P1
UniProt accession	P05386
Gene	RPLP1
Organism	Homo sapiens
Length	114 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (111)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.55
Duchenne muscular dystrophy · score 0.50
cystic fibrosis · score 0.50
influenza · score 0.46
lysosomal storage disease · score 0.37
Becker muscular dystrophy · score 0.29
qualitative or quantitative defects of dystrophin · score 0.26
platelet count · score 0.21
lymphocyte count · score 0.20
rheumatoid arthritis · score 0.20

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P05386-F1	alphafold	PREDICTED	69.56	—

Amino-acid sequence (114 residues)

MASVSELACI YSALILHDDE VTVTEDKINA LIKAAGVNVE PFWPGLFAKA LANVNIGSLI CNVGAGGPAP AAGAAPAGGP APSTAAAPAE EKKVEAKKEE SEESDDDMGF GLFD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards