Large ribosomal subunit protein uL10 (RPLP0)

About Large ribosomal subunit protein uL10

Large ribosomal subunit protein uL10 (RPLP0) is a protein from Homo sapiens identified by UniProt accession P05388, 317 residues long. MolForge cross-references it against 0 known binders and 127 disease associations.

Target properties

Protein name	Large ribosomal subunit protein uL10
UniProt accession	P05388
Gene	RPLP0
Organism	Homo sapiens
Length	317 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (127)

Diseases linked to this target (Open Targets).

Duchenne muscular dystrophy · score 0.50
cystic fibrosis · score 0.50
influenza · score 0.46
Becker muscular dystrophy · score 0.29
clear cell renal carcinoma · score 0.27
endometrial cancer · score 0.27
qualitative or quantitative defects of dystrophin · score 0.26
glioblastoma multiforme · score 0.15
aniridia · score 0.09
diffuse large B-cell lymphoma · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P05388-F1	alphafold	PREDICTED	79.28	—

Amino-acid sequence (317 residues)

MPREDRATWK SNYFLKIIQL LDDYPKCFIV GADNVGSKQM QQIRMSLRGK AVVLMGKNTM MRKAIRGHLE NNPALEKLLP HIRGNVGFVF TKEDLTEIRD MLLANKVPAA ARAGAIAPCE VTVPAQNTGL GPEKTSFFQA LGITTKISRG TIEILSDVQL IKTGDKVGAS EATLLNMLNI SPFSFGLVIQ QVFDNGSIYN PEVLDITEET LHSRFLEGVR NVASVCLQIG YPTVASVPHS IINGYKRVLA LSVETDYTFP LAEKVKAFLA DPSAFVAAAP VAAATTAAPA AAAAPAKVEA KEESEESDED MGFGLFD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards