Transcription factor Jun (JUN)

About Transcription factor Jun

Transcription factor Jun (JUN) is a protein from Homo sapiens identified by UniProt accession P05412, 331 residues long. MolForge cross-references it against 0 known binders and 898 disease associations.

Target properties

Protein name	Transcription factor Jun
UniProt accession	P05412
Gene	JUN
Organism	Homo sapiens
Length	331 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (898)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.56
cancer · score 0.49
colorectal adenocarcinoma · score 0.40
colon adenocarcinoma · score 0.37
skin squamous cell carcinoma · score 0.37
Endometrial Endometrioid Adenocarcinoma · score 0.37
Alzheimer disease · score 0.37
superficial spreading melanoma · score 0.37
squamous cell lung carcinoma · score 0.36
lung adenocarcinoma · score 0.35

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P05412-F1	alphafold	PREDICTED	61.24	—

Amino-acid sequence (331 residues)

MTAKMETTFY DDALNASFLP SESGPYGYSN PKILKQSMTL NLADPVGSLK PHLRAKNSDL LTSPDVGLLK LASPELERLI IQSSNGHITT TPTPTQFLCP KNVTDEQEGF AEGFVRALAE LHSQNTLPSV TSAAQPVNGA GMVAPAVASV AGGSGSGGFS ASLHSEPPVY ANLSNFNPGA LSSGGGAPSY GAAGLAFPAQ PQQQQQPPHH LPQQMPVQHP RLQALKEEPQ TVPEMPGETP PLSPIDMESQ ERIKAERKRM RNRIAASKCR KRKLERIARL EEKVKTLKAQ NSELASTANM LREQVAQLKQ KVMNHVNSGC QLMLTQQLQT F

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards