DNA-directed RNA polymerase III subunit RPC4 (POLR3D)

About DNA-directed RNA polymerase III subunit RPC4

DNA-directed RNA polymerase III subunit RPC4 (POLR3D) is a protein from Homo sapiens identified by UniProt accession P05423, 398 residues long. MolForge cross-references it against 0 known binders and 15 disease associations.

Target properties

Protein name	DNA-directed RNA polymerase III subunit RPC4
UniProt accession	P05423
Gene	POLR3D
Organism	Homo sapiens
Length	398 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (15)

Diseases linked to this target (Open Targets).

endometrial cancer · score 0.18
thrombocytopenia 4 · score 0.04
platelet-type bleeding disorder 15 · score 0.04
thrombocytopenia 2 · score 0.03
bleeding disorder, platelet-type, 24 · score 0.03
macrothrombocytopenia, isolated, 2, autosomal dominant · score 0.03
platelet-type bleeding disorder 10 · score 0.03
autosomal dominant macrothrombocytopenia · score 0.03
DIAPH1-related sensorineural hearing loss-thrombocytopenia syndrome · score 0.03
thrombocytopenia 3 · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P05423-F1	alphafold	PREDICTED	64.13	—

Amino-acid sequence (398 residues)

MSEGNAAGEP STPGGPRPLL TGARGLIGRR PAPPLTPGRL PSIRSRDLTL GGVKKKTFTP NIISRKIKEE PKEEVTVKKE KRERDRDRQR EGHGRGRGRP EVIQSHSIFE QGPAEMMKKK GNWDKTVDVS DMGPSHIINI KKEKRETDEE TKQILRMLEK DDFLDDPGLR NDTRNMPVQL PLAHSGWLFK EENDEPDVKP WLAGPKEEDM EVDIPAVKVK EEPRDEEEEA KMKAPPKAAR KTPGLPKDVS VAELLRELSL TKEEELLFLQ LPDTLPGQPP TQDIKPIKTE VQGEDGQVVL IKQEKDREAK LAENACTLAD LTEGQVGKLL IRKSGRVQLL LGKVTLDVTM GTACSFLQEL VSVGLGDSRT GEMTVLGHVK HKLVCSPDFE SLLDHKHR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards