Heparin cofactor 2 (SERPIND1)

About Heparin cofactor 2

Heparin cofactor 2 (SERPIND1) is a protein from Homo sapiens identified by UniProt accession P05546, 499 residues long. MolForge cross-references it against 0 known binders and 183 disease associations.

Target properties

Protein name	Heparin cofactor 2
UniProt accession	P05546
Gene	SERPIND1
Organism	Homo sapiens
Length	499 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (183)

Diseases linked to this target (Open Targets).

heparin cofactor 2 deficiency · score 0.72
Venous thrombosis · score 0.67
hemorrhage · score 0.27
neurodegenerative disease · score 0.26
mean platelet volume · score 0.25
cutaneous melanoma · score 0.23
breast adenocarcinoma · score 0.21
squamous cell lung carcinoma · score 0.20
platelet component distribution width · score 0.20
head and neck squamous cell carcinoma · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P05546-F1	alphafold	PREDICTED	79.65	—

Amino-acid sequence (499 residues)

MKHSLNALLI FLIITSAWGG SKGPLDQLEK GGETAQSADP QWEQLNNKNL SMPLLPADFH KENTVTNDWI PEGEEDDDYL DLEKIFSEDD DYIDIVDSLS VSPTDSDVSA GNILQLFHGK SRIQRLNILN AKFAFNLYRV LKDQVNTFDN IFIAPVGIST AMGMISLGLK GETHEQVHSI LHFKDFVNAS SKYEITTIHN LFRKLTHRLF RRNFGYTLRS VNDLYIQKQF PILLDFKTKV REYYFAEAQI ADFSDPAFIS KTNNHIMKLT KGLIKDALEN IDPATQMMIL NCIYFKGSWV NKFPVEMTHN HNFRLNEREV VKVSMMQTKG NFLAANDQEL DCDILQLEYV GGISMLIVVP HKMSGMKTLE AQLTPRVVER WQKSMTNRTR EVLLPKFKLE KNYNLVESLK LMGIRMLFDK NGNMAGISDQ RIAIDLFKHQ GTITVNEEGT QATTVTTVGF MPLSTQVRFT VDRPFLFLIY EHRTSCLLFM GRVANPSRS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards