Transcription factor AP-2-alpha (TFAP2A)

About Transcription factor AP-2-alpha

Transcription factor AP-2-alpha (TFAP2A) is a protein from Homo sapiens identified by UniProt accession P05549, 437 residues long. MolForge cross-references it against 0 known binders and 502 disease associations.

Target properties

Protein name	Transcription factor AP-2-alpha
UniProt accession	P05549
Gene	TFAP2A
Organism	Homo sapiens
Length	437 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (502)

Diseases linked to this target (Open Targets).

branchiooculofacial syndrome · score 0.80
Branchio-oculo-facial syndrome · score 0.70
genetic disorder · score 0.52
neurodegenerative disease · score 0.49
cleft lip · score 0.37
microphthalmia · score 0.34
epicanthal fold · score 0.34
High palate · score 0.34
Hypertelorism · score 0.34
Epicanthus · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P05549-F1	alphafold	PREDICTED	67.93	—

Amino-acid sequence (437 residues)

MLWKLTDNIK YEDCEDRHDG TSNGTARLPQ LGTVGQSPYT SAPPLSHTPN ADFQPPYFPP PYQPIYPQSQ DPYSHVNDPY SLNPLHAQPQ PQHPGWPGQR QSQESGLLHT HRGLPHQLSG LDPRRDYRRH EDLLHGPHAL SSGLGDLSIH SLPHAIEEVP HVEDPGINIP DQTVIKKGPV SLSKSNSNAV SAIPINKDNL FGGVVNPNEV FCSVPGRLSL LSSTSKYKVT VAEVQRRLSP PECLNASLLG GVLRRAKSKN GGRSLREKLD KIGLNLPAGR RKAANVTLLT SLVEGEAVHL ARDFGYVCET EFPAKAVAEF LNRQHSDPNE QVTRKNMLLA TKQICKEFTD LLAQDRSPLG NSRPNPILEP GIQSCLTHFN LISHGFGSPA VCAAVTALQN YLTEALKAMD KMYLSNNPNS HTDNNAKSSD KEEKHRK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards