Keratin, type I cytoskeletal 18 (KRT18)

About Keratin, type I cytoskeletal 18

Keratin, type I cytoskeletal 18 (KRT18) is a protein from Homo sapiens identified by UniProt accession P05783, 430 residues long. MolForge cross-references it against 0 known binders and 576 disease associations.

Target properties

Protein name	Keratin, type I cytoskeletal 18
UniProt accession	P05783
Gene	KRT18
Organism	Homo sapiens
Length	430 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (576)

Diseases linked to this target (Open Targets).

cirrhosis, familial · score 0.57
cirrhosis of liver · score 0.54
creatinine measurement · score 0.24
glioblastoma multiforme · score 0.19
cystatin C measurement · score 0.19
Cleft palate · score 0.18
cleft lip · score 0.18
prostate carcinoma · score 0.14
esophageal cancer · score 0.14
neoplasm · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P05783-F1	alphafold	PREDICTED	78.65	—

Amino-acid sequence (430 residues)

MSFTTRSTFS TNYRSLGSVQ APSYGARPVS SAASVYAGAG GSGSRISVSR STSFRGGMGS GGLATGIAGG LAGMGGIQNE KETMQSLNDR LASYLDRVRS LETENRRLES KIREHLEKKG PQVRDWSHYF KIIEDLRAQI FANTVDNARI VLQIDNARLA ADDFRVKYET ELAMRQSVEN DIHGLRKVID DTNITRLQLE TEIEALKEEL LFMKKNHEEE VKGLQAQIAS SGLTVEVDAP KSQDLAKIMA DIRAQYDELA RKNREELDKY WSQQIEESTT VVTTQSAEVG AAETTLTELR RTVQSLEIDL DSMRNLKASL ENSLREVEAR YALQMEQLNG ILLHLESELA QTRAEGQRQA QEYEALLNIK VKLEAEIATY RRLLEDGEDF NLGDALDSSN SMQTIQKTTT RRIVDGKVVS ETNDTKVLRH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards