Keratin, type II cytoskeletal 8 (KRT8)

About Keratin, type II cytoskeletal 8

Keratin, type II cytoskeletal 8 (KRT8) is a protein from Homo sapiens identified by UniProt accession P05787, 483 residues long. MolForge cross-references it against 0 known binders and 486 disease associations.

Target properties

Protein name	Keratin, type II cytoskeletal 8
UniProt accession	P05787
Gene	KRT8
Organism	Homo sapiens
Length	483 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (486)

Diseases linked to this target (Open Targets).

cirrhosis, familial · score 0.49
neurodegenerative disease · score 0.47
cirrhosis of liver · score 0.46
prostate carcinoma · score 0.36
serum alanine aminotransferase measurement · score 0.32
aspartate aminotransferase measurement · score 0.31
serum gamma-glutamyl transferase measurement · score 0.23
lysosomal storage disease · score 0.22
male reproductive organ cancer · score 0.22
Alzheimer disease · score 0.22

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P05787-F1	alphafold	PREDICTED	74.16	—

Amino-acid sequence (483 residues)

MSIRVTQKSY KVSTSGPRAF SSRSYTSGPG SRISSSSFSR VGSSNFRGGL GGGYGGASGM GGITAVTVNQ SLLSPLVLEV DPNIQAVRTQ EKEQIKTLNN KFASFIDKVR FLEQQNKMLE TKWSLLQQQK TARSNMDNMF ESYINNLRRQ LETLGQEKLK LEAELGNMQG LVEDFKNKYE DEINKRTEME NEFVLIKKDV DEAYMNKVEL ESRLEGLTDE INFLRQLYEE EIRELQSQIS DTSVVLSMDN SRSLDMDSII AEVKAQYEDI ANRSRAEAES MYQIKYEELQ SLAGKHGDDL RRTKTEISEM NRNISRLQAE IEGLKGQRAS LEAAIADAEQ RGELAIKDAN AKLSELEAAL QRAKQDMARQ LREYQELMNV KLALDIEIAT YRKLLEGEES RLESGMQNMS IHTKTTSGYA GGLSSAYGGL TSPGLSYSLG SSFGSGAGSS SFSRTSSSRA VVVKKIETRD GKLVSESSDV LPK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards