About Beta-crystallin A3
Beta-crystallin A3 (CRYBA1) is a protein
from Homo sapiens identified by UniProt accession
P05813, 215 residues long.
MolForge cross-references it against 0 known binders and
166 disease associations.
Target properties
| Protein name | Beta-crystallin A3 |
|---|
| UniProt accession | P05813 |
|---|
| Gene | CRYBA1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 215 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (166)
Diseases linked to this target (Open Targets).
- Cataract with Y-shaped suture opacities · score 0.74
- early-onset non-syndromic cataract · score 0.56
- Posterior polar cataract · score 0.56
- genetic disorder · score 0.41
- early-onset nuclear cataract · score 0.37
- early-onset posterior polar cataract · score 0.37
- early-onset sutural cataract · score 0.37
- mean reticulocyte volume · score 0.34
- leukocyte count · score 0.30
- brain stem volume measurement · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P05813-F1 | alphafold | PREDICTED | 87.53 | — |
Amino-acid sequence (215 residues)
METQAEQQEL ETLPTTKMAQ TNPTPGSLGP WKITIYDQEN FQGKRMEFTS SCPNVSERSF DNVRSLKVES GAWIGYEHTS FCGQQFILER GEYPRWDAWS GSNAYHIERL MSFRPICSAN HKESKMTIFE KENFIGRQWE ISDDYPSLQA MGWFNNEVGS MKIQSGAWVC YQYPGYRGYQ YILECDHHGG DYKHWREWGS HAQTSQIQSI RRIQQ
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