About Myosin light chain 1/3, skeletal muscle isoform
Myosin light chain 1/3, skeletal muscle isoform (MYL1) is a protein
from Homo sapiens identified by UniProt accession
P05976, 194 residues long.
MolForge cross-references it against 0 known binders and
60 disease associations.
Target properties
| Protein name | Myosin light chain 1/3, skeletal muscle isoform |
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| UniProt accession | P05976 |
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| Gene | MYL1 |
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| Organism | Homo sapiens |
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| Length | 194 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (60)
Diseases linked to this target (Open Targets).
- congenital fiber-type disproportion myopathy · score 0.60
- serum metabolite measurement · score 0.32
- breast adenocarcinoma · score 0.23
- head and neck squamous cell carcinoma · score 0.21
- gastric adenocarcinoma · score 0.19
- lung adenocarcinoma · score 0.18
- esophageal cancer · score 0.17
- endometrial cancer · score 0.13
- clear cell renal carcinoma · score 0.11
- leukocyte count · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P05976-F1 | alphafold | PREDICTED | 87.85 | — |
Amino-acid sequence (194 residues)
MAPKKDVKKP VAAAAAAPAP APAPAPAPAP AKPKEEKIDL SAIKIEFSKE QQDEFKEAFL LFDRTGDSKI TLSQVGDVLR ALGTNPTNAE VRKVLGNPSN EELNAKKIEF EQFLPMMQAI SNNKDQATYE DFVEGLRVFD KEGNGTVMGA ELRHVLATLG EKMKEEEVEA LMAGQEDSNG CINYEAFVKH IMSI
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