T-cell surface glycoprotein CD5 (CD5)

About T-cell surface glycoprotein CD5

T-cell surface glycoprotein CD5 (CD5) is a protein from Homo sapiens identified by UniProt accession P06127, 495 residues long. MolForge cross-references it against 0 known binders and 604 disease associations.

Target properties

Protein name	T-cell surface glycoprotein CD5
UniProt accession	P06127
Gene	CD5
Organism	Homo sapiens
Length	495 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (604)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.27
gut microbiome measurement · score 0.27
eosinophil count · score 0.27
eosinophil percentage of leukocytes · score 0.22
systolic blood pressure · score 0.20
smoking status measurement · score 0.20
multiple sclerosis · score 0.16
adolescent idiopathic scoliosis · score 0.12
diffuse large B-cell lymphoma · score 0.12
chronic lymphocytic leukemia · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P06127-F1	alphafold	PREDICTED	73.36	—

Amino-acid sequence (495 residues)

MPMGSLQPLA TLYLLGMLVA SCLGRLSWYD PDFQARLTRS NSKCQGQLEV YLKDGWHMVC SQSWGRSSKQ WEDPSQASKV CQRLNCGVPL SLGPFLVTYT PQSSIICYGQ LGSFSNCSHS RNDMCHSLGL TCLEPQKTTP PTTRPPPTTT PEPTAPPRLQ LVAQSGGQHC AGVVEFYSGS LGGTISYEAQ DKTQDLENFL CNNLQCGSFL KHLPETEAGR AQDPGEPREH QPLPIQWKIQ NSSCTSLEHC FRKIKPQKSG RVLALLCSGF QPKVQSRLVG GSSICEGTVE VRQGAQWAAL CDSSSARSSL RWEEVCREQQ CGSVNSYRVL DAGDPTSRGL FCPHQKLSQC HELWERNSYC KKVFVTCQDP NPAGLAAGTV ASIILALVLL VVLLVVCGPL AYKKLVKKFR QKKQRQWIGP TGMNQNMSFH RNHTATVRSH AENPTASHVD NEYSQPPRNS HLSAYPALEG ALHRSSMQPD NSSDSDYDLH GAQRL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards