Uroporphyrinogen decarboxylase (UROD)

About Uroporphyrinogen decarboxylase

Uroporphyrinogen decarboxylase (UROD) is a protein from Homo sapiens identified by UniProt accession P06132, 367 residues long. MolForge cross-references it against 0 known binders and 84 disease associations.

Target properties

Protein name	Uroporphyrinogen decarboxylase
UniProt accession	P06132
Gene	UROD
Organism	Homo sapiens
Length	367 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (84)

Diseases linked to this target (Open Targets).

Familial porphyria cutanea tarda · score 0.83
porphyria cutanea tarda · score 0.60
hepatoerythropoietic porphyria · score 0.58
neurodegenerative disease · score 0.39
UROD-related inherited porphyria · score 0.37
leukemia · score 0.37
sporadic porphyria cutanea tarda · score 0.27
genetic disorder · score 0.18
vital capacity · score 0.03
porphyria · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P06132-F1	alphafold	PREDICTED	96.73	—

Amino-acid sequence (367 residues)

MEANGLGPQG FPELKNDTFL RAAWGEETDY TPVWCMRQAG RYLPEFRETR AAQDFFSTCR SPEACCELTL QPLRRFPLDA AIIFSDILVV PQALGMEVTM VPGKGPSFPE PLREEQDLER LRDPEVVASE LGYVFQAITL TRQRLAGRVP LIGFAGAPWT LMTYMVEGGG SSTMAQAKRW LYQRPQASHQ LLRILTDALV PYLVGQVVAG AQALQLFESH AGHLGPQLFN KFALPYIRDV AKQVKARLRE AGLAPVPMII FAKDGHFALE ELAQAGYEVV GLDWTVAPKK ARECVGKTVT LQGNLDPCAL YASEEEIGQL VKQMLDDFGP HRYIANLGHG LYPDMDPEHV GAFVDAVHKH SRLLRQN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards