About UDP-glucuronosyltransferase 2B4
UDP-glucuronosyltransferase 2B4 (UGT2B4) is a protein
from Homo sapiens identified by UniProt accession
P06133, 528 residues long.
MolForge cross-references it against 0 known binders and
36 disease associations.
Target properties
| Protein name | UDP-glucuronosyltransferase 2B4 |
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| UniProt accession | P06133 |
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| Gene | UGT2B4 |
|---|
| Organism | Homo sapiens |
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| Length | 528 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (36)
Diseases linked to this target (Open Targets).
- serum gamma-glutamyl transferase measurement · score 0.28
- cutaneous melanoma · score 0.19
- lung adenocarcinoma · score 0.17
- glioblastoma multiforme · score 0.17
- squamous cell lung carcinoma · score 0.10
- neoplasm · score 0.04
- colorectal cancer · score 0.04
- pancreatic adenocarcinoma · score 0.03
- C-X-C motif chemokine 10 measurement · score 0.03
- gut microbiome measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P06133-F1 | alphafold | PREDICTED | 94.00 | — |
Amino-acid sequence (528 residues)
MSMKWTSALL LIQLSCYFSS GSCGKVLVWP TEFSHWMNIK TILDELVQRG HEVTVLASSA SISFDPNSPS TLKFEVYPVS LTKTEFEDII KQLVKRWAEL PKDTFWSYFS QVQEIMWTFN DILRKFCKDI VSNKKLMKKL QESRFDVVLA DAVFPFGELL AELLKIPFVY SLRFSPGYAI EKHSGGLLFP PSYVPVVMSE LSDQMTFIER VKNMIYVLYF EFWFQIFDMK KWDQFYSEVL GRPTTLSETM AKADIWLIRN YWDFQFPHPL LPNVEFVGGL HCKPAKPLPK EMEEFVQSSG ENGVVVFSLG SMVSNTSEER ANVIASALAK IPQKVLWRFD GNKPDTLGLN TRLYKWIPQN DLLGHPKTRA FITHGGANGI YEAIYHGIPM VGVPLFADQP DNIAHMKAKG AAVSLDFHTM SSTDLLNALK TVINDPLYKE NAMKLSRIHH DQPVKPLDRA VFWIEFVMRH KGAKHLRVAA HDLTWFQYHS LDVTGFLLAC VATVIFIITK CLFCVWKFVR TGKKGKRD
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