Alpha-galactosidase A (GLA)

About Alpha-galactosidase A

Alpha-galactosidase A (GLA) is a protein from Homo sapiens identified by UniProt accession P06280, 429 residues long. MolForge cross-references it against 0 known binders and 354 disease associations.

Target properties

Protein name	Alpha-galactosidase A
UniProt accession	P06280
Gene	GLA
Organism	Homo sapiens
Length	429 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (354)

Diseases linked to this target (Open Targets).

Fabry disease · score 0.90
cardiomyopathy · score 0.61
Angiokeratoma corporis diffusum · score 0.58
Abnormality of the cardiovascular system · score 0.55
response to deoxygalactonojirimycin · score 0.54
hypertrophic cardiomyopathy · score 0.54
Renal insufficiency · score 0.53
kidney failure · score 0.46
familial hypertrophic cardiomyopathy · score 0.46
stroke · score 0.40

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P06280-F1	alphafold	PREDICTED	94.31	—

Amino-acid sequence (429 residues)

MQLRNPELHL GCALALRFLA LVSWDIPGAR ALDNGLARTP TMGWLHWERF MCNLDCQEEP DSCISEKLFM EMAELMVSEG WKDAGYEYLC IDDCWMAPQR DSEGRLQADP QRFPHGIRQL ANYVHSKGLK LGIYADVGNK TCAGFPGSFG YYDIDAQTFA DWGVDLLKFD GCYCDSLENL ADGYKHMSLA LNRTGRSIVY SCEWPLYMWP FQKPNYTEIR QYCNHWRNFA DIDDSWKSIK SILDWTSFNQ ERIVDVAGPG GWNDPDMLVI GNFGLSWNQQ VTQMALWAIM AAPLFMSNDL RHISPQAKAL LQDKDVIAIN QDPLGKQGYQ LRQGDNFEVW ERPLSGLAWA VAMINRQEIG GPRSYTIAVA SLGKGVACNP ACFITQLLPV KRKLGFYEWT SRLRSHINPT GTVLLQLENT MQMSLKDLL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards