Immunoglobulin kappa variable 4-1 (IGKV4-1)

About Immunoglobulin kappa variable 4-1

Immunoglobulin kappa variable 4-1 (IGKV4-1) is a protein from Homo sapiens identified by UniProt accession P06312, 121 residues long. MolForge cross-references it against 0 known binders and 81 disease associations.

Target properties

Protein name	Immunoglobulin kappa variable 4-1
UniProt accession	P06312
Gene	IGKV4-1
Organism	Homo sapiens
Length	121 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	LOW
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (81)

Diseases linked to this target (Open Targets).

cutaneous Leishmaniasis · score 0.59
squamous cell carcinoma · score 0.07
sebaceous of Jadassohn nevus · score 0.07
Barrett's esophagus · score 0.07
esophageal adenocarcinoma · score 0.05
osteosarcoma · score 0.04
central nervous system cancer · score 0.04
rheumatoid arthritis · score 0.03
actinic keratosis · score 0.03
Acute hepatic failure · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P06312-F1	alphafold	PREDICTED	90.64	—

Amino-acid sequence (121 residues)

MVLQTQVFIS LLLWISGAYG DIVMTQSPDS LAVSLGERAT INCKSSQSVL YSSNNKNYLA WYQQKPGQPP KLLIYWASTR ESGVPDRFSG SGSGTDFTLT ISSLQAEDVA VYYCQQYYST P

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards