Immunoglobulin kappa variable 5-2 (IGKV5-2)

About Immunoglobulin kappa variable 5-2

Immunoglobulin kappa variable 5-2 (IGKV5-2) is a protein from Homo sapiens identified by UniProt accession P06315, 115 residues long. MolForge cross-references it against 0 known binders and 132 disease associations.

Target properties

Protein name	Immunoglobulin kappa variable 5-2
UniProt accession	P06315
Gene	IGKV5-2
Organism	Homo sapiens
Length	115 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	LOW
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (132)

Diseases linked to this target (Open Targets).

cutaneous Leishmaniasis · score 0.59
infection · score 0.05
infect · score 0.05
cancer · score 0.03
ulcerative colitis · score 0.02
viral disease · score 0.02
atherosclerosis · score 0.01
experimental autoimmune encephalomyelitis · score 0.01
neoplasm · score 0.01
acute lymphoblastic leukemia · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P06315-F1	alphafold	PREDICTED	89.78	—

Amino-acid sequence (115 residues)

MGSQVHLLSF LLLWISDTRA ETTLTQSPAF MSATPGDKVN ISCKASQDID DDMNWYQQKP GEAAIFIIQE ATTLVPGIPP RFSGSGYGTD FTLTINNIES EDAAYYFCLQ HDNFP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards