Immunoglobulin heavy variable 4-34 (IGHV4-34)

About Immunoglobulin heavy variable 4-34

Immunoglobulin heavy variable 4-34 (IGHV4-34) is a protein from Homo sapiens identified by UniProt accession P06331, 123 residues long. MolForge cross-references it against 0 known binders and 24 disease associations.

Target properties

Protein name	Immunoglobulin heavy variable 4-34
UniProt accession	P06331
Gene	IGHV4-34
Organism	Homo sapiens
Length	123 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	LOW
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (24)

Diseases linked to this target (Open Targets).

cutaneous Leishmaniasis · score 0.59
Barrett's esophagus · score 0.05
osteosarcoma · score 0.03
ulcerative colitis · score 0.03
esophageal adenocarcinoma · score 0.02
Crohn's disease · score 0.02
periodontitis · score 0.02
rheumatoid arthritis · score 0.01
chronic lymphocytic leukemia · score 0.01
chronic interstitial cystitis · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P06331-F1	alphafold	PREDICTED	90.17	—

Amino-acid sequence (123 residues)

MDLLHKNMKH LWFFLLLVAA PRWVLSQVQL QQWGAGLLKP SETLSLTCAV YGGSFSGYYW SWIRQPPGKG LEWIGEINHS GSTNYNPSLK SRVTISVDTS KNQFSLKLSS VTAADTAVYY CAR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards