Prothymosin alpha (PTMA)

About Prothymosin alpha

Prothymosin alpha (PTMA) is a protein from Homo sapiens identified by UniProt accession P06454, 111 residues long. MolForge cross-references it against 0 known binders and 200 disease associations.

Target properties

Protein name	Prothymosin alpha
UniProt accession	P06454
Gene	PTMA
Organism	Homo sapiens
Length	111 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (200)

Diseases linked to this target (Open Targets).

lymphocyte count · score 0.43
leukocyte count · score 0.42
neutrophil count · score 0.42
Testicular Germ Cell Tumor · score 0.37
myeloid white cell count · score 0.36
monocyte percentage of leukocytes · score 0.29
calcium measurement · score 0.27
mean corpuscular hemoglobin · score 0.26
mean corpuscular hemoglobin concentration · score 0.16
acute myeloid leukemia · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P06454-F1	alphafold	PREDICTED	58.38	—

Amino-acid sequence (111 residues)

MSDAAVDTSS EITTKDLKEK KEVVEEAENG RDAPANGNAE NEENGEQEAD NEVDEEEEEG GEEEEEEEEG DGEEEDGDED EEAESATGKR AAEDDEDDDV DTKKQKTDED D

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards