About ATP synthase F(1) complex subunit beta, mitochondrial
ATP synthase F(1) complex subunit beta, mitochondrial (ATP5F1B) is a protein
from Homo sapiens identified by UniProt accession
P06576, 529 residues long.
MolForge cross-references it against 0 known binders and
133 disease associations.
Target properties
| Protein name | ATP synthase F(1) complex subunit beta, mitochondrial |
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| UniProt accession | P06576 |
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| Gene | ATP5F1B |
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| Organism | Homo sapiens |
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| Length | 529 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (133)
Diseases linked to this target (Open Targets).
- hypermetabolism due to uncoupled mitochondrial oxidative phosphorylation 2 · score 0.45
- platelet component distribution width · score 0.18
- reticulocyte count · score 0.09
- mean platelet volume · score 0.09
- platelet count · score 0.09
- cancer · score 0.08
- hepatocellular carcinoma · score 0.08
- aspartate aminotransferase measurement · score 0.07
- neoplasm · score 0.05
- snoring measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P06576-F1 | alphafold | PREDICTED | 85.23 | — |
Amino-acid sequence (529 residues)
MLGFVGRVAA APASGALRRL TPSASLPPAQ LLLRAAPTAV HPVRDYAAQT SPSPKAGAAT GRIVAVIGAV VDVQFDEGLP PILNALEVQG RETRLVLEVA QHLGESTVRT IAMDGTEGLV RGQKVLDSGA PIKIPVGPET LGRIMNVIGE PIDERGPIKT KQFAPIHAEA PEFMEMSVEQ EILVTGIKVV DLLAPYAKGG KIGLFGGAGV GKTVLIMELI NNVAKAHGGY SVFAGVGERT REGNDLYHEM IESGVINLKD ATSKVALVYG QMNEPPGARA RVALTGLTVA EYFRDQEGQD VLLFIDNIFR FTQAGSEVSA LLGRIPSAVG YQPTLATDMG TMQERITTTK KGSITSVQAI YVPADDLTDP APATTFAHLD ATTVLSRAIA ELGIYPAVDP LDSTSRIMDP NIVGSEHYDV ARGVQKILQD YKSLQDIIAI LGMDELSEED KLTVSRARKI QRFLSQPFQV AEVFTGHMGK LVPLKETIKG FQQILAGEYD HLPEQAFYMV GPIEEAVAKA DKLAEEHSS
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