Apolipoprotein A-IV (APOA4)

About Apolipoprotein A-IV

Apolipoprotein A-IV (APOA4) is a protein from Homo sapiens identified by UniProt accession P06727, 396 residues long. MolForge cross-references it against 0 known binders and 338 disease associations.

Target properties

Protein name	Apolipoprotein A-IV
UniProt accession	P06727
Gene	APOA4
Organism	Homo sapiens
Length	396 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (338)

Diseases linked to this target (Open Targets).

AL amyloidosis · score 0.46
triglyceride measurement · score 0.42
total cholesterol measurement · score 0.40
high density lipoprotein cholesterol measurement · score 0.33
low density lipoprotein cholesterol measurement · score 0.33
apolipoprotein B measurement · score 0.24
lung adenocarcinoma · score 0.24
cutaneous melanoma · score 0.23
apolipoprotein A-IV measurement · score 0.21
apolipoprotein A 1 measurement · score 0.16

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P06727-F1	alphafold	PREDICTED	80.81	—

Amino-acid sequence (396 residues)

MFLKAVVLTL ALVAVAGARA EVSADQVATV MWDYFSQLSN NAKEAVEHLQ KSELTQQLNA LFQDKLGEVN TYAGDLQKKL VPFATELHER LAKDSEKLKE EIGKELEELR ARLLPHANEV SQKIGDNLRE LQQRLEPYAD QLRTQVSTQA EQLRRQLTPY AQRMERVLRE NADSLQASLR PHADELKAKI DQNVEELKGR LTPYADEFKV KIDQTVEELR RSLAPYAQDT QEKLNHQLEG LTFQMKKNAE ELKARISASA EELRQRLAPL AEDVRGNLRG NTEGLQKSLA ELGGHLDQQV EEFRRRVEPY GENFNKALVQ QMEQLRQKLG PHAGDVEGHL SFLEKDLRDK VNSFFSTFKE KESQDKTLSL PELEQQQEQQ QEQQQEQVQM LAPLES

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards