T-cell surface antigen CD2 (CD2)

About T-cell surface antigen CD2

T-cell surface antigen CD2 (CD2) is a protein from Homo sapiens identified by UniProt accession P06729, 351 residues long. MolForge cross-references it against 0 known binders and 400 disease associations.

Target properties

Protein name	T-cell surface antigen CD2
UniProt accession	P06729
Gene	CD2
Organism	Homo sapiens
Length	351 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (400)

Diseases linked to this target (Open Targets).

psoriasis · score 0.64
immune system disease · score 0.37
pityriasis rubra pilaris · score 0.37
atopic eczema · score 0.37
eosinophil count · score 0.33
rheumatoid arthritis · score 0.32
thyroid disease · score 0.30
Thyroid preparation use measurement · score 0.30
graft versus host disease · score 0.27
eosinophil percentage of leukocytes · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P06729-F1	alphafold	PREDICTED	77.72	—

Amino-acid sequence (351 residues)

MSFPCKFVAS FLLIFNVSSK GAVSKEITNA LETWGALGQD INLDIPSFQM SDDIDDIKWE KTSDKKKIAQ FRKEKETFKE KDTYKLFKNG TLKIKHLKTD DQDIYKVSIY DTKGKNVLEK IFDLKIQERV SKPKISWTCI NTTLTCEVMN GTDPELNLYQ DGKHLKLSQR VITHKWTTSL SAKFKCTAGN KVSKESSVEP VSCPEKGLDI YLIIGICGGG SLLMVFVALL VFYITKRKKQ RSRRNDEELE TRAHRVATEE RGRKPHQIPA STPQNPATSQ HPPPPPGHRS QAPSHRPPPP GHRVQHQPQK RPPAPSGTQV HQQKGPPLPR PRVQPKPPHG AAENSLSPSS N

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards