Eukaryotic translation initiation factor 4E (EIF4E)

About Eukaryotic translation initiation factor 4E

Eukaryotic translation initiation factor 4E (EIF4E) is a protein from Homo sapiens identified by UniProt accession P06730, 217 residues long. MolForge cross-references it against 0 known binders and 322 disease associations.

Target properties

Protein name	Eukaryotic translation initiation factor 4E
UniProt accession	P06730
Gene	EIF4E
Organism	Homo sapiens
Length	217 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (322)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
autism · score 0.42
mathematical ability · score 0.33
platelet component distribution width · score 0.27
vertebral joint disease · score 0.26
lung adenocarcinoma · score 0.26
alcohol consumption measurement · score 0.25
cystatin C measurement · score 0.19
high density lipoprotein cholesterol measurement · score 0.16
non-small cell lung carcinoma · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P06730-F1	alphafold	PREDICTED	90.95	—

Amino-acid sequence (217 residues)

MATVEPETTP TPNPPTTEEE KTESNQEVAN PEHYIKHPLQ NRWALWFFKN DKSKTWQANL RLISKFDTVE DFWALYNHIQ LSSNLMPGCD YSLFKDGIEP MWEDEKNKRG GRWLITLNKQ QRRSDLDRFW LETLLCLIGE SFDDYSDDVC GAVVNVRAKG DKIAIWTTEC ENREAVTHIG RVYKERLGLP PKIVIGYQSH ADTATKSGST TKNRFVV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards