Creatine kinase M-type (CKM)

About Creatine kinase M-type

Creatine kinase M-type (CKM) is a protein from Homo sapiens identified by UniProt accession P06732, 381 residues long. MolForge cross-references it against 0 known binders and 189 disease associations.

Target properties

Protein name	Creatine kinase M-type
UniProt accession	P06732
Gene	CKM
Organism	Homo sapiens
Length	381 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (189)

Diseases linked to this target (Open Targets).

self reported educational attainment · score 0.36
blood protein measurement · score 0.27
intelligence · score 0.23
serum alanine aminotransferase measurement · score 0.23
cognitive function measurement · score 0.23
neurodegenerative disease · score 0.22
neoplasm · score 0.09
body height · score 0.08
body mass index · score 0.08
intrahepatic cholangiocarcinoma · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P06732-F1	alphafold	PREDICTED	94.84	—

Amino-acid sequence (381 residues)

MPFGNTHNKF KLNYKPEEEY PDLSKHNNHM AKVLTLELYK KLRDKETPSG FTVDDVIQTG VDNPGHPFIM TVGCVAGDEE SYEVFKELFD PIISDRHGGY KPTDKHKTDL NHENLKGGDD LDPNYVLSSR VRTGRSIKGY TLPPHCSRGE RRAVEKLSVE ALNSLTGEFK GKYYPLKSMT EKEQQQLIDD HFLFDKPVSP LLLASGMARD WPDARGIWHN DNKSFLVWVN EEDHLRVISM EKGGNMKEVF RRFCVGLQKI EEIFKKAGHP FMWNQHLGYV LTCPSNLGTG LRGGVHVKLA HLSKHPKFEE ILTRLRLQKR GTGGVDTAAV GSVFDVSNAD RLGSSEVEQV QLVVDGVKLM VEMEKKLEKG QSIDDMIPAQ K

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards