Alpha-enolase (ENO1)

About Alpha-enolase

Alpha-enolase (ENO1) is a protein from Homo sapiens identified by UniProt accession P06733, 434 residues long. MolForge cross-references it against 0 known binders and 374 disease associations.

Target properties

Protein name	Alpha-enolase
UniProt accession	P06733
Gene	ENO1
Organism	Homo sapiens
Length	434 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (374)

Diseases linked to this target (Open Targets).

tuberculosis · score 0.37
platelet count · score 0.29
neutrophil count · score 0.28
neurodegenerative disease · score 0.27
platelet crit · score 0.27
myeloid white cell count · score 0.25
reticulocyte count · score 0.20
basophil count · score 0.20
Immature Reticulocyte Fraction Measurement · score 0.20
leukocyte count · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P06733-F1	alphafold	PREDICTED	97.61	—

Amino-acid sequence (434 residues)

MSILKIHARE IFDSRGNPTV EVDLFTSKGL FRAAVPSGAS TGIYEALELR DNDKTRYMGK GVSKAVEHIN KTIAPALVSK KLNVTEQEKI DKLMIEMDGT ENKSKFGANA ILGVSLAVCK AGAVEKGVPL YRHIADLAGN SEVILPVPAF NVINGGSHAG NKLAMQEFMI LPVGAANFRE AMRIGAEVYH NLKNVIKEKY GKDATNVGDE GGFAPNILEN KEGLELLKTA IGKAGYTDKV VIGMDVAASE FFRSGKYDLD FKSPDDPSRY ISPDQLADLY KSFIKDYPVV SIEDPFDQDD WGAWQKFTAS AGIQVVGDDL TVTNPKRIAK AVNEKSCNCL LLKVNQIGSV TESLQACKLA QANGWGVMVS HRSGETEDTF IADLVVGLCT GQIKTGAPCR SERLAKYNQL LRIEEELGSK AKFAGRNFRN PLAK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards