About Glucose-6-phosphate isomerase
Glucose-6-phosphate isomerase (GPI) is a protein
from Homo sapiens identified by UniProt accession
P06744, 558 residues long.
MolForge cross-references it against 0 known binders and
314 disease associations.
Target properties
| Protein name | Glucose-6-phosphate isomerase |
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| UniProt accession | P06744 |
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| Gene | GPI |
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| Organism | Homo sapiens |
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| Length | 558 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (314)
Diseases linked to this target (Open Targets).
- hemolytic anemia due to glucophosphate isomerase deficiency · score 0.83
- mean corpuscular volume · score 0.37
- hereditary spherocytosis · score 0.28
- hemolytic anemia · score 0.26
- breast adenocarcinoma · score 0.23
- endometrial cancer · score 0.22
- lung adenocarcinoma · score 0.21
- genetic disorder · score 0.19
- squamous cell lung carcinoma · score 0.19
- head and neck squamous cell carcinoma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P06744-F1 | alphafold | PREDICTED | 97.93 | — |
Amino-acid sequence (558 residues)
MAALTRDPQF QKLQQWYREH RSELNLRRLF DANKDRFNHF SLTLNTNHGH ILVDYSKNLV TEDVMRMLVD LAKSRGVEAA RERMFNGEKI NYTEGRAVLH VALRNRSNTP ILVDGKDVMP EVNKVLDKMK SFCQRVRSGD WKGYTGKTIT DVINIGIGGS DLGPLMVTEA LKPYSSGGPR VWYVSNIDGT HIAKTLAQLN PESSLFIIAS KTFTTQETIT NAETAKEWFL QAAKDPSAVA KHFVALSTNT TKVKEFGIDP QNMFEFWDWV GGRYSLWSAI GLSIALHVGF DNFEQLLSGA HWMDQHFRTT PLEKNAPVLL ALLGIWYINC FGCETHAMLP YDQYLHRFAA YFQQGDMESN GKYITKSGTR VDHQTGPIVW GEPGTNGQHA FYQLIHQGTK MIPCDFLIPV QTQHPIRKGL HHKILLANFL AQTEALMRGK STEEARKELQ AAGKSPEDLE RLLPHKVFEG NRPTNSIVFT KLTPFMLGAL VAMYEHKIFV QGIIWDINSF DQWGVELGKQ LAKKIEPELD GSAQVTSHDA STNGLINFIK QQREARVQ
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