About Nucleophosmin
Nucleophosmin (NPM1) is a protein
from Homo sapiens identified by UniProt accession
P06748, 294 residues long.
MolForge cross-references it against 0 known binders and
571 disease associations.
Target properties
| Protein name | Nucleophosmin |
|---|
| UniProt accession | P06748 |
|---|
| Gene | NPM1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 294 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (571)
Diseases linked to this target (Open Targets).
- cancer · score 0.71
- acute myeloid leukemia · score 0.68
- non-small cell lung carcinoma · score 0.65
- anaplastic large cell lymphoma · score 0.58
- neoplasm · score 0.55
- neurodegenerative disease · score 0.55
- HIV infection · score 0.54
- dyskeratosis congenita · score 0.50
- inflammatory myofibroblastic tumor · score 0.47
- diffuse large B-cell lymphoma · score 0.45
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P06748-F1 | alphafold | PREDICTED | 73.25 | — |
Amino-acid sequence (294 residues)
MEDSMDMDMS PLRPQNYLFG CELKADKDYH FKVDNDENEH QLSLRTVSLG AGAKDELHIV EAEAMNYEGS PIKVTLATLK MSVQPTVSLG GFEITPPVVL RLKCGSGPVH ISGQHLVAVE EDAESEDEEE EDVKLLSISG KRSAPGGGSK VPQKKVKLAA DEDDDDDDEE DDDEDDDDDD FDDEEAEEKA PVKKSIRDTP AKNAQKSNQN GKDSKPSSTP RSKGQESFKK QEKTPKTPKG PSSVEDIKAK MQASIEKGGS LPKVEAKFIN YVKNCFRMTD QEAIQDLWQW RKSL
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