Tropomyosin alpha-3 chain (TPM3)

About Tropomyosin alpha-3 chain

Tropomyosin alpha-3 chain (TPM3) is a protein from Homo sapiens identified by UniProt accession P06753, 285 residues long. MolForge cross-references it against 0 known binders and 280 disease associations.

Target properties

Protein name	Tropomyosin alpha-3 chain
UniProt accession	P06753
Gene	TPM3
Organism	Homo sapiens
Length	285 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (280)

Diseases linked to this target (Open Targets).

congenital myopathy 4B, autosomal recessive · score 0.72
congenital fiber-type disproportion myopathy · score 0.70
cap myopathy · score 0.68
intermediate nemaline myopathy · score 0.62
childhood-onset nemaline myopathy · score 0.62
nemaline myopathy · score 0.51
TPM3-related myopathy · score 0.49
cancer · score 0.47
genetic disorder · score 0.38
anaplastic large cell lymphoma · score 0.38

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P06753-F1	alphafold	PREDICTED	91.67	—

Amino-acid sequence (285 residues)

MMEAIKKKMQ MLKLDKENAL DRAEQAEAEQ KQAEERSKQL EDELAAMQKK LKGTEDELDK YSEALKDAQE KLELAEKKAA DAEAEVASLN RRIQLVEEEL DRAQERLATA LQKLEEAEKA ADESERGMKV IENRALKDEE KMELQEIQLK EAKHIAEEAD RKYEEVARKL VIIEGDLERT EERAELAESK CSELEEELKN VTNNLKSLEA QAEKYSQKED KYEEEIKILT DKLKEAETRA EFAERSVAKL EKTIDDLEDE LYAQKLKYKA ISEELDHALN DMTSI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards