About Beta-hexosaminidase subunit alpha
Beta-hexosaminidase subunit alpha (HEXA) is a protein
from Homo sapiens identified by UniProt accession
P06865, 529 residues long.
MolForge cross-references it against 0 known binders and
155 disease associations.
Target properties
| Protein name | Beta-hexosaminidase subunit alpha |
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| UniProt accession | P06865 |
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| Gene | HEXA |
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| Organism | Homo sapiens |
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| Length | 529 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (155)
Diseases linked to this target (Open Targets).
- Tay-Sachs disease · score 0.86
- genetic disorder · score 0.54
- GM1 gangliosidosis · score 0.50
- Tay-Sachs disease, B1 variant · score 0.49
- Tay-Sachs disease AB variant · score 0.46
- GM2-gangliosidosis, AB variant · score 0.46
- Tay-Sachs disease, b variant, juvenile form · score 0.37
- Tay-Sachs disease, b variant, infantile form · score 0.37
- Tay-Sachs disease, B variant, adult form · score 0.37
- GM2-ganglioside accumulation · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P06865-F1 | alphafold | PREDICTED | 93.43 | — |
Amino-acid sequence (529 residues)
MTSSRLWFSL LLAAAFAGRA TALWPWPQNF QTSDQRYVLY PNNFQFQYDV SSAAQPGCSV LDEAFQRYRD LLFGSGSWPR PYLTGKRHTL EKNVLVVSVV TPGCNQLPTL ESVENYTLTI NDDQCLLLSE TVWGALRGLE TFSQLVWKSA EGTFFINKTE IEDFPRFPHR GLLLDTSRHY LPLSSILDTL DVMAYNKLNV FHWHLVDDPS FPYESFTFPE LMRKGSYNPV THIYTAQDVK EVIEYARLRG IRVLAEFDTP GHTLSWGPGI PGLLTPCYSG SEPSGTFGPV NPSLNNTYEF MSTFFLEVSS VFPDFYLHLG GDEVDFTCWK SNPEIQDFMR KKGFGEDFKQ LESFYIQTLL DIVSSYGKGY VVWQEVFDNK VKIQPDTIIQ VWREDIPVNY MKELELVTKA GFRALLSAPW YLNRISYGPD WKDFYIVEPL AFEGTPEQKA LVIGGEACMW GEYVDNTNLV PRLWPRAGAV AERLWSNKLT SDLTFAYERL SHFRCELLRR GVQAQPLNVG FCEQEFEQT
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