Histone H2B type 1-J (H2BC11)

About Histone H2B type 1-J

Histone H2B type 1-J (H2BC11) is a protein from Homo sapiens identified by UniProt accession P06899, 126 residues long. MolForge cross-references it against 0 known binders and 62 disease associations.

Target properties

Protein name	Histone H2B type 1-J
UniProt accession	P06899
Gene	H2BC11
Organism	Homo sapiens
Length	126 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (62)

Diseases linked to this target (Open Targets).

viral disease · score 0.50
infectious disease · score 0.50
breast carcinoma · score 0.37
cancer · score 0.37
melanoma · score 0.37
schizophrenia · score 0.22
BMI-adjusted waist circumference · score 0.20
mean corpuscular volume · score 0.19
psoriasis · score 0.17
intelligence · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P06899-F1	alphafold	PREDICTED	85.47	—

Amino-acid sequence (126 residues)

MPEPAKSAPA PKKGSKKAVT KAQKKDGKKR KRSRKESYSI YVYKVLKQVH PDTGISSKAM GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR LLLPGELAKH AVSEGTKAVT KYTSAK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards