Glia-derived nexin (SERPINE2)

About Glia-derived nexin

Glia-derived nexin (SERPINE2) is a protein from Homo sapiens identified by UniProt accession P07093, 398 residues long. MolForge cross-references it against 0 known binders and 188 disease associations.

Target properties

Protein name	Glia-derived nexin
UniProt accession	P07093
Gene	SERPINE2
Organism	Homo sapiens
Length	398 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (188)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.50
mean platelet volume · score 0.47
body height · score 0.45
platelet-derived growth factor BB measurement · score 0.44
interleukin 10 measurement · score 0.37
inflammatory biomarker measurement · score 0.33
CCL13 measurement · score 0.31
BMI-adjusted waist circumference · score 0.29
vascular endothelial growth factor measurement · score 0.28
interleukin 12 measurement · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P07093-F1	alphafold	PREDICTED	88.36	—

Amino-acid sequence (398 residues)

MNWHLPLFLL ASVTLPSICS HFNPLSLEEL GSNTGIQVFN QIVKSRPHDN IVISPHGIAS VLGMLQLGAD GRTKKQLAMV MRYGVNGVGK ILKKINKAIV SKKNKDIVTV ANAVFVKNAS EIEVPFVTRN KDVFQCEVRN VNFEDPASAC DSINAWVKNE TRDMIDNLLS PDLIDGVLTR LVLVNAVYFK GLWKSRFQPE NTKKRTFVAA DGKSYQVPML AQLSVFRCGS TSAPNDLWYN FIELPYHGES ISMLIALPTE SSTPLSAIIP HISTKTIDSW MSIMVPKRVQ VILPKFTAVA QTDLKEPLKV LGITDMFDSS KANFAKITTG SENLHVSHIL QKAKIEVSED GTKASAATTA ILIARSSPPW FIVDRPFLFF IRHNPTGAVL FMGQINKP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards