About Gastric triacylglycerol lipase
Gastric triacylglycerol lipase (LIPF) is a protein
from Homo sapiens identified by UniProt accession
P07098, 398 residues long.
MolForge cross-references it against 0 known binders and
62 disease associations.
Target properties
| Protein name | Gastric triacylglycerol lipase |
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| UniProt accession | P07098 |
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| Gene | LIPF |
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| Organism | Homo sapiens |
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| Length | 398 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (62)
Diseases linked to this target (Open Targets).
- obesity · score 0.57
- type 2 diabetes mellitus · score 0.47
- Hepatitis · score 0.37
- Hepatic steatosis · score 0.37
- blood protein measurement · score 0.32
- infertility · score 0.26
- lung adenocarcinoma · score 0.11
- cutaneous melanoma · score 0.11
- esophageal cancer · score 0.10
- squamous cell lung carcinoma · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P07098-F1 | alphafold | PREDICTED | 89.77 | — |
Amino-acid sequence (398 residues)
MWLLLTMASL ISVLGTTHGL FGKLHPGSPE VTMNISQMIT YWGYPNEEYE VVTEDGYILE VNRIPYGKKN SGNTGQRPVV FLQHGLLASA TNWISNLPNN SLAFILADAG YDVWLGNSRG NTWARRNLYY SPDSVEFWAF SFDEMAKYDL PATIDFIVKK TGQKQLHYVG HSQGTTIGFI AFSTNPSLAK RIKTFYALAP VATVKYTKSL INKLRFVPQS LFKFIFGDKI FYPHNFFDQF LATEVCSREM LNLLCSNALF IICGFDSKNF NTSRLDVYLS HNPAGTSVQN MFHWTQAVKS GKFQAYDWGS PVQNRMHYDQ SQPPYYNVTA MNVPIAVWNG GKDLLADPQD VGLLLPKLPN LIYHKEIPFY NHLDFIWAMD APQEVYNDIV SMISEDKK
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