Epoxide hydrolase 1 (EPHX1)

About Epoxide hydrolase 1

Epoxide hydrolase 1 (EPHX1) is a protein from Homo sapiens identified by UniProt accession P07099, 455 residues long. MolForge cross-references it against 0 known binders and 257 disease associations.

Target properties

Protein name	Epoxide hydrolase 1
UniProt accession	P07099
Gene	EPHX1
Organism	Homo sapiens
Length	455 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (257)

Diseases linked to this target (Open Targets).

sex hormone-binding globulin measurement · score 0.37
Insulin resistance · score 0.37
insulin resistance · score 0.37
Lipodystrophy · score 0.37
hypercholanemia, familial · score 0.37
lipodystrophy · score 0.37
cystic fibrosis · score 0.19
glioblastoma multiforme · score 0.16
appendicular lean mass · score 0.12
hypercholanemia, familial 1 · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P07099-F1	alphafold	PREDICTED	95.12	—

Amino-acid sequence (455 residues)

MWLEILLTSV LGFAIYWFIS RDKEETLPLE DGWWGPGTRS AAREDDSIRP FKVETSDEEI HDLHQRIDKF RFTPPLEDSC FHYGFNSNYL KKVISYWRNE FDWKKQVEIL NRYPHFKTKI EGLDIHFIHV KPPQLPAGHT PKPLLMVHGW PGSFYEFYKI IPLLTDPKNH GLSDEHVFEV ICPSIPGYGF SEASSKKGFN SVATARIFYK LMLRLGFQEF YIQGGDWGSL ICTNMAQLVP SHVKGLHLNM ALVLSNFSTL TLLLGQRFGR FLGLTERDVE LLYPVKEKVF YSLMRESGYM HIQCTKPDTV GSALNDSPVG LAAYILEKFS TWTNTEFRYL EDGGLERKFS LDDLLTNVML YWTTGTIISS QRFYKENLGQ GWMTQKHERM KVYVPTGFSA FPFELLHTPE KWVRFKYPKL ISYSYMVRGG HFAAFEEPEL LAQDIRKFLS VLERQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards