About Tyrosine 3-monooxygenase
Tyrosine 3-monooxygenase (TH) is a protein
from Homo sapiens identified by UniProt accession
P07101, 528 residues long.
MolForge cross-references it against 0 known binders and
726 disease associations.
Target properties
| Protein name | Tyrosine 3-monooxygenase |
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| UniProt accession | P07101 |
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| Gene | TH |
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| Organism | Homo sapiens |
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| Length | 528 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (726)
Diseases linked to this target (Open Targets).
- TH-deficient dopa-responsive dystonia · score 0.83
- Autosomal recessive dopa-responsive dystonia · score 0.81
- dopa-responsive dystonia · score 0.66
- tyrosine hydroxylase deficiency · score 0.56
- dystonia 5 · score 0.53
- adrenal gland pheochromocytoma · score 0.47
- Dystonia · score 0.42
- dystonic disorder · score 0.42
- genetic disorder · score 0.42
- Intellectual disability · score 0.42
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P07101-F1 | alphafold | PREDICTED | 80.77 | — |
Amino-acid sequence (528 residues)
MPTPDATTPQ AKGFRRAVSE LDAKQAEAIM VRGQGAPGPS LTGSPWPGTA APAASYTPTP RSPRFIGRRQ SLIEDARKER EAAVAAAAAA VPSEPGDPLE AVAFEEKEGK AVLNLLFSPR ATKPSALSRA VKVFETFEAK IHHLETRPAQ RPRAGGPHLE YFVRLEVRRG DLAALLSGVR QVSEDVRSPA GPKVPWFPRK VSELDKCHHL VTKFDPDLDL DHPGFSDQVY RQRRKLIAEI AFQYRHGDPI PRVEYTAEEI ATWKEVYTTL KGLYATHACG EHLEAFALLE RFSGYREDNI PQLEDVSRFL KERTGFQLRP VAGLLSARDF LASLAFRVFQ CTQYIRHASS PMHSPEPDCC HELLGHVPML ADRTFAQFSQ DIGLASLGAS DEEIEKLSTL YWFTVEFGLC KQNGEVKAYG AGLLSSYGEL LHCLSEEPEI RAFDPEAAAV QPYQDQTYQS VYFVSESFSD AKDKLRSYAS RIQRPFSVKF DPYTLAIDVL DSPQAVRRSL EGVQDELDTL AHALSAIG
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