About Neurofilament light polypeptide
Neurofilament light polypeptide (NEFL) is a protein
from Homo sapiens identified by UniProt accession
P07196, 543 residues long.
MolForge cross-references it against 0 known binders and
757 disease associations.
Target properties
| Protein name | Neurofilament light polypeptide |
|---|
| UniProt accession | P07196 |
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| Gene | NEFL |
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| Organism | Homo sapiens |
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| Length | 543 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (757)
Diseases linked to this target (Open Targets).
- Charcot-Marie-Tooth disease type 1F · score 0.79
- Charcot-Marie-Tooth disease type 2E · score 0.79
- Autosomal dominant Charcot-Marie-Tooth disease type 2E · score 0.76
- Charcot-Marie-Tooth disease, dominant intermediate G · score 0.70
- Charcot-Marie-Tooth disease · score 0.64
- autosomal dominant intermediate Charcot-Marie-Tooth disease type G · score 0.55
- genetic disorder · score 0.49
- peripheral neuropathy · score 0.48
- Charcot-Marie-Tooth disease type 2 · score 0.37
- Charcot-Marie-Tooth disease type 2B5 · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P07196-F1 | alphafold | PREDICTED | 73.03 | — |
Amino-acid sequence (543 residues)
MSSFSYEPYY STSYKRRYVE TPRVHISSVR SGYSTARSAY SSYSAPVSSS LSVRRSYSSS SGSLMPSLEN LDLSQVAAIS NDLKSIRTQE KAQLQDLNDR FASFIERVHE LEQQNKVLEA ELLVLRQKHS EPSRFRALYE QEIRDLRLAA EDATNEKQAL QGEREGLEET LRNLQARYEE EVLSREDAEG RLMEARKGAD EAALARAELE KRIDSLMDEI SFLKKVHEEE IAELQAQIQY AQISVEMDVT KPDLSAALKD IRAQYEKLAA KNMQNAEEWF KSRFTVLTES AAKNTDAVRA AKDEVSESRR LLKAKTLEIE ACRGMNEALE KQLQELEDKQ NADISAMQDT INKLENELRT TKSEMARYLK EYQDLLNVKM ALDIEIAAYR KLLEGEETRL SFTSVGSITS GYSQSSQVFG RSAYGGLQTS SYLMSTRSFP SYYTSHVQEE QIEVEETIEA AKAEEAKDEP PSEGEAEEEE KDKEEAEEEE AAEEEEAAKE ESEEAKEEEE GGEGEEGEET KEAEEEEKKV EGAGEEQAAK KKD
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