About Thrombomodulin
Thrombomodulin (THBD) is a protein
from Homo sapiens identified by UniProt accession
P07204, 575 residues long.
MolForge cross-references it against 0 known binders and
600 disease associations.
Target properties
| Protein name | Thrombomodulin |
|---|
| UniProt accession | P07204 |
|---|
| Gene | THBD |
|---|
| Organism | Homo sapiens |
|---|
| Length | 575 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (600)
Diseases linked to this target (Open Targets).
- thrombomodulin-related bleeding disorder · score 0.75
- atypical hemolytic-uremic syndrome with thrombomodulin anomaly · score 0.70
- Venous thrombosis · score 0.46
- atypical hemolytic-uremic syndrome · score 0.46
- thrombomodulin measurement · score 0.45
- blood protein measurement · score 0.41
- Abnormal bleeding · score 0.39
- Thrombocytopenia · score 0.35
- neurodegenerative disease · score 0.31
- Abnormal thrombosis · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P07204-F1 | alphafold | PREDICTED | 78.65 | — |
Amino-acid sequence (575 residues)
MLGVLVLGAL ALAGLGFPAP AEPQPGGSQC VEHDCFALYP GPATFLNASQ ICDGLRGHLM TVRSSVAADV ISLLLNGDGG VGRRRLWIGL QLPPGCGDPK RLGPLRGFQW VTGDNNTSYS RWARLDLNGA PLCGPLCVAV SAAEATVPSE PIWEEQQCEV KADGFLCEFH FPATCRPLAV EPGAAAAAVS ITYGTPFAAR GADFQALPVG SSAAVAPLGL QLMCTAPPGA VQGHWAREAP GAWDCSVENG GCEHACNAIP GAPRCQCPAG AALQADGRSC TASATQSCND LCEHFCVPNP DQPGSYSCMC ETGYRLAADQ HRCEDVDDCI LEPSPCPQRC VNTQGGFECH CYPNYDLVDG ECVEPVDPCF RANCEYQCQP LNQTSYLCVC AEGFAPIPHE PHRCQMFCNQ TACPADCDPN TQASCECPEG YILDDGFICT DIDECENGGF CSGVCHNLPG TFECICGPDS ALARHIGTDC DSGKVDGGDS GSGEPPPSPT PGSTLTPPAV GLVHSGLLIG ISIASLCLVV ALLALLCHLR KKQGAARAKM EYKCAAPSKE VVLQHVRTER TPQRL
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