Phosphoglycerate kinase 2 (PGK2)

About Phosphoglycerate kinase 2

Phosphoglycerate kinase 2 (PGK2) is a protein from Homo sapiens identified by UniProt accession P07205, 417 residues long. MolForge cross-references it against 0 known binders and 76 disease associations.

Target properties

Protein name	Phosphoglycerate kinase 2
UniProt accession	P07205
Gene	PGK2
Organism	Homo sapiens
Length	417 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (76)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.17
endometrial cancer · score 0.12
azoospermia · score 0.09
male infertility with teratozoospermia due to single gene mutation · score 0.08
spermatogenic failure 55 · score 0.07
spermatogenic failure 3 · score 0.07
spermatogenic failure 7 · score 0.06
spermatogenic failure 29 · score 0.06
partial chromosome Y deletion · score 0.06
spermatogenic failure 10 · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P07205-F1	alphafold	PREDICTED	96.26	—

Amino-acid sequence (417 residues)

MSLSKKLTLD KLDVRGKRVI MRVDFNVPMK KNQITNNQRI KASIPSIKYC LDNGAKAVVL MSHLGRPDGV PMPDKYSLAP VAVELKSLLG KDVLFLKDCV GAEVEKACAN PAPGSVILLE NLRFHVEEEG KGQDPSGKKI KAEPDKIEAF RASLSKLGDV YVNDAFGTAH RAHSSMVGVN LPHKASGFLM KKELDYFAKA LENPVRPFLA ILGGAKVADK IQLIKNMLDK VNEMIIGGGM AYTFLKVLNN MEIGASLFDE EGAKIVKDIM AKAQKNGVRI TFPVDFVTGD KFDENAQVGK ATVASGISPG WMGLDCGPES NKNHAQVVAQ ARLIVWNGPL GVFEWDAFAK GTKALMDEIV KATSKGCITV IGGGDTATCC AKWNTEDKVS HVSTGGGASL ELLEGKILPG VEALSNM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards