About Vitamin K-dependent protein S
Vitamin K-dependent protein S (PROS1) is a protein
from Homo sapiens identified by UniProt accession
P07225, 676 residues long.
MolForge cross-references it against 0 known binders and
331 disease associations.
Target properties
| Protein name | Vitamin K-dependent protein S |
|---|
| UniProt accession | P07225 |
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| Gene | PROS1 |
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| Organism | Homo sapiens |
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| Length | 676 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (331)
Diseases linked to this target (Open Targets).
- thrombophilia due to protein S deficiency, autosomal dominant · score 0.83
- hereditary thrombophilia due to congenital protein S deficiency · score 0.75
- protein S deficiency · score 0.66
- pulmonary embolism · score 0.53
- venous thromboembolism · score 0.52
- deep vein thrombosis · score 0.43
- cor pulmonale · score 0.38
- Abnormal bleeding · score 0.29
- blood coagulation disease · score 0.28
- hematologic disease · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P07225-F1 | alphafold | PREDICTED | 82.91 | — |
Amino-acid sequence (676 residues)
MRVLGGRCGA LLACLLLVLP VSEANFLSKQ QASQVLVRKR RANSLLEETK QGNLERECIE ELCNKEEARE VFENDPETDY FYPKYLVCLR SFQTGLFTAA RQSTNAYPDL RSCVNAIPDQ CSPLPCNEDG YMSCKDGKAS FTCTCKPGWQ GEKCEFDINE CKDPSNINGG CSQICDNTPG SYHCSCKNGF VMLSNKKDCK DVDECSLKPS ICGTAVCKNI PGDFECECPE GYRYNLKSKS CEDIDECSEN MCAQLCVNYP GGYTCYCDGK KGFKLAQDQK SCEVVSVCLP LNLDTKYELL YLAEQFAGVV LYLKFRLPEI SRFSAEFDFR TYDSEGVILY AESIDHSAWL LIALRGGKIE VQLKNEHTSK ITTGGDVINN GLWNMVSVEE LEHSISIKIA KEAVMDINKP GPLFKPENGL LETKVYFAGF PRKVESELIK PINPRLDGCI RSWNLMKQGA SGIKEIIQEK QNKHCLVTVE KGSYYPGSGI AQFHIDYNNV SSAEGWHVNV TLNIRPSTGT GVMLALVSGN NTVPFAVSLV DSTSEKSQDI LLSVENTVIY RIQALSLCSD QQSHLEFRVN RNNLELSTPL KIETISHEDL QRQLAVLDKA MKAKVATYLG GLPDVPFSAT PVNAFYNGCM EVNINGVQLD LDEAISKHND IRAHSCPSVW KKTKNS
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