Protein disulfide-isomerase (P4HB)

About Protein disulfide-isomerase

Protein disulfide-isomerase (P4HB) is a protein from Homo sapiens identified by UniProt accession P07237, 508 residues long. MolForge cross-references it against 0 known binders and 278 disease associations.

Target properties

Protein name	Protein disulfide-isomerase
UniProt accession	P07237
Gene	P4HB
Organism	Homo sapiens
Length	508 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (278)

Diseases linked to this target (Open Targets).

Cole-Carpenter syndrome · score 0.73
osteogenesis imperfecta type 1 · score 0.37
cutaneous melanoma · score 0.25
lung adenocarcinoma · score 0.25
breast adenocarcinoma · score 0.25
genetic disorder · score 0.19
squamous cell lung carcinoma · score 0.16
endometrial cancer · score 0.14
glioblastoma multiforme · score 0.12
gastric adenocarcinoma · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P07237-F1	alphafold	PREDICTED	88.48	—

Amino-acid sequence (508 residues)

MLRRALLCLA VAALVRADAP EEEDHVLVLR KSNFAEALAA HKYLLVEFYA PWCGHCKALA PEYAKAAGKL KAEGSEIRLA KVDATEESDL AQQYGVRGYP TIKFFRNGDT ASPKEYTAGR EADDIVNWLK KRTGPAATTL PDGAAAESLV ESSEVAVIGF FKDVESDSAK QFLQAAEAID DIPFGITSNS DVFSKYQLDK DGVVLFKKFD EGRNNFEGEV TKENLLDFIK HNQLPLVIEF TEQTAPKIFG GEIKTHILLF LPKSVSDYDG KLSNFKTAAE SFKGKILFIF IDSDHTDNQR ILEFFGLKKE ECPAVRLITL EEEMTKYKPE SEELTAERIT EFCHRFLEGK IKPHLMSQEL PEDWDKQPVK VLVGKNFEDV AFDEKKNVFV EFYAPWCGHC KQLAPIWDKL GETYKDHENI VIAKMDSTAN EVEAVKVHSF PTLKFFPASA DRTVIDYNGE RTLDGFKKFL ESGGQDGAGD DDDLEDLEEA EEPDMEEDDD QKAVKDEL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards